Research and Clinical Validation

Our Research and Clinical Data

We're actively advancing our own clinical research to better understand and support patients undergoing assisted reproduction. Our most recent Institutional Review Board (IRB) approvals focus on:

Autologous Bio Serum Particles (BSP; patient-derived EV-enriched plasma) as an Adjunct to Assisted Reproduction in Women with Thin Endometrium or Recurrent Implantation Failure (RIF): A Safety and Feasibility Study

This study is designed to explore how BSPs can safely and effectively be used as an intrauterine adjunct to help improve endometrial receptivity and implantation potential for women facing persistent challenges with assisted reproductive treatments. It represents an important step toward building our own body of evidence to complement existing peer-reviewed research and demonstrate the real-world impact of our work.

Status: IRB Approved

Pilot Study – Autologous Bio Serum Particles (BSP; patient-derived EV-enriched plasma) for Ovarian Rejuvenation in Women with Diminished Ovarian Reserve (DOR): A Safety, Feasibility, and Early Signals Study

This next phase expands our research into the potential of BSPs for ovarian rejuvenation, aiming to explore safety, feasibility, and early biological and clinical signals in women with DOR—another population facing critical unmet needs in assisted reproduction.

Status: IRB Approved

We're pleased to share that the IRB for the RIF study has been approved, marking a significant milestone in our clinical research program. In addition, we've just received approval for the DOR study, expanding our research into the potential of BSPs for ovarian rejuvenation—another population facing critical unmet needs in assisted reproduction.

Peer-Reviewed Evidence

This section compiles key scientific studies and published papers that investigate the role of extracellular vesicles, including exosomes and other nanoscale particles, in fertility and reproductive outcomes. Each article is presented with a clear summary of its purpose, methodology, and results.

Beneath each study, key findings and concise notes are provided to highlight the most important takeaways. These notes are intended to support understanding of the research and provide helpful context for interpreting the results.

Together, these curated studies offer an organized, evidence-based foundation for understanding how extracellular vesicles may influence fertility, embryo development, and reproductive health.

Female Fertility Applications

  • Unveiling the role of extracellular vesicles in reproductive success and uterine diseases – a systematic review
  • Messenger roles of extracellular vesicles during fertilization of gametes, development and implantation: Recent advances
  • Exosomes spectacular role in reproduction
  • Exosomes in the field of reproduction
  • Comparative analysis of the use of autologous exosomes…
  • Extracellular vesicles: key mediators in in vitro embryo production
  • Extracellular vesicles affecting embryo development in vitro: a potential culture medium supplement
  • Endometrial exosomes/microvesicles in the uterine microenvironment…
  • The complicated effects of extracellular vesicles and their cargos on embryo implantation
Scientific illustration of DNA and cellular research